15 Best Cities in Panama to Visit

Panama is a land where the old and the new harmoniously dance together, creating a mosaic of captivating cities waiting to be explored. Nestled at the crossroads of North and South America, Panama is a country that beckons travelers with its diverse landscapes, rich history, and vibrant tapestry of cultures. We got to visit during the summer, meaning it was very hot, but there was still plenty to enjoy in Panama. From the historic Casco Viejo to the pristine beaches of the San Blas Islands, Panama has more variety than I expected!

While most visitors (including us) start their journey in the bustling metropolis of Panama City, there are plenty of amazing cities in Panama to visit. Some of these cities have incredible views of the countryside so break free from the skyscrapers and canal and head out to see more of what Panama has to offer travelers.

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1. Panama City

Panama City is a dynamic and bustling metropolis with a vibrant economy that offers a wide range of attractions and amenities. The city is home to a number of cultural sites such as the Panama Canal, Casco Viejo (the historic district), and the Panama Viejo ruins, attracting history enthusiasts and art aficionados alike. Its strategic location makes it a hub for international travel, with the Tocumen International Airport providing easy access to and from the city.

Panama City’s modern infrastructure, lively nightlife, and favorable climate make it a popular destination for tourists, expats, and retirees. The city boasts a variety of entertainment options, from trendy bars and clubs to world-class restaurants offering diverse cuisines. Its tropical climate ensures sunny skies and warm temperatures, providing an ideal setting for outdoor activities and beach excursions.

Me and Spencer with the Panama City skyline. Panama city is one of the best cities in Panama!
Me and Spencer with the Panama City skyline.

2. El Valle de Anton

El Valle de Anton is a charming town located in the crater of an extinct volcano in Panama. Its unique location provides visitors with stunning views of lush forests, waterfalls, and diverse wildlife, making it a haven for nature lovers and expats alike. The town boasts a range of activities such as hiking trails through the surrounding mountains, relaxing hot springs, and bustling markets offering local crafts and fresh produce.

One of the key draws of El Valle is its close proximity to Panama City, allowing residents to easily access urban amenities while still enjoying the tranquility of small-town life. The town’s mild climate is another attractive feature, and its welcoming community vibe makes it an ideal place for expats to settle down. With its natural beauty, outdoor activities, and proximity to urban conveniences, it’s no wonder El Valle is considered one of the best cities in Panama for expats seeking a peaceful and enriching lifestyle.

El Valle de Anton is one of the best cities in Panama
The volcano near El Valle de Anton, Panama.

3. Santiago

Santiago is a bustling city located in the heart of Panama, with a population of approximately 90,000 people. It is strategically positioned on the Pan-American Highway, making it a crucial transportation hub for the region. As the capital of Veraguas province, Santiago serves as an important administrative and economic center.

Despite its size, Santiago offers a range of amenities for its residents and visitors. One notable attraction is the largest shopping mall outside of Panama City, providing a wide array of shops, restaurants, and entertainment options.

The climate in Santiago is characterized by warm temperatures and a tropical savanna climate, with a distinct wet and dry season. The slower pace of life in Santiago allows locals and tourists to enjoy the natural beauty of the surrounding area, including lush forests and nearby beaches.

Santiago is one of the best cities in Panama
Santiago Center Square. Photo by Deposit Photos.

4. Santa Fé

Santa Fé, Panama, is a charming mountain town known for its natural beauty and outdoor activities. One of the top attractions in the area is Santa Fé National Park, which offers opportunities for hiking, bird-watching, and wildlife spotting. Visitors can also explore the stunning waterfalls in the region, such as the popular Las Yayas waterfall, which is great for swimming and picnicking. Additionally, taking a coffee tour is a must-do activity in Santa Fé, as the area is known for its high-quality, locally grown coffee.

Accommodations in Santa Fé are limited, with a handful of small hotels, guesthouses, and eco-lodges available. It is recommended to book accommodations well in advance, especially during peak tourist seasons. Despite the limited options, the area is seeing a growing expat community, with foreigners drawn to Santa Fé’s tranquil atmosphere, beautiful scenery, and opportunities for outdoor recreation. This has led to the development of some expat-friendly businesses and services in the area, making it easier for international visitors to enjoy their time in Santa Fé. Whether you’re a nature lover, adventure seeker, or simply seeking a peaceful retreat, Santa Fé has something to offer for everyone.

Read more: How to visit the san blas islands

5. La Palma

La Palma, located in the Darien province of Panama, is a bustling city known for its dense population and surrounding natural attractions. The city is surrounded by tropical jungles, mountains, and beaches, making it a popular destination for tourists seeking outdoor adventures.

One of the most popular activities in La Palma is canoeing on the Tuira or Chucunaque rivers, which wind their way through the lush jungles and provide a unique way to experience the natural beauty of the area. Hiking is also a favorite pastime, with numerous trails that lead to stunning viewpoints and hidden waterfalls. For those who enjoy fishing, the rivers offer opportunities to catch a variety of freshwater fish in a pristine natural setting.

La Palma offers an ideal mix of natural beauty and outdoor activities, making it a must-visit destination for adventurous travelers looking to explore the diverse landscapes of the Darien province.

6. Portobelo

Portobelo in Panama offers a rich history and stunning natural beauty for visitors to explore. One of the top attractions in Portobelo is the Spanish forts, including the impressive San Jeronimo and Santiago forts, which offer insight into the region’s colonial past. The town itself is a UNESCO World Heritage site, with its well-preserved historical architecture and cultural significance.

For outdoor enthusiasts, renting a kayak to explore the old fortifications along the coast is a must-do activity. Playa Huerta is a beautiful beach where visitors can relax and enjoy the sun and sea. Additionally, taking a boat trip to the San Blas Islands or Cartagena is a popular option, allowing for a unique and unforgettable experience on the water.

Whether you’re exploring the Spanish forts, relaxing on the beach, or embarking on a boat trip to nearby islands, Portobelo is a destination not to be missed.

The ruins of Portobelo, one of the best cities in Panama.
The ruins in Portobelo, Panama. Photo by Deposit Photos.

7. David

Located in western Panama, David is a charming city known for its affordability, natural beauty, and well-developed infrastructure. Surrounded by lush greenery and majestic mountains, the city offers a tranquil and picturesque setting for residents and visitors.

David enjoys a tropical climate with warm temperatures year-round, making it an ideal destination for those seeking outdoor recreation. The city is equipped with a wide range of amenities, including shopping centers, restaurants, and cultural attractions, providing ample opportunities for leisure and entertainment.

Outdoor enthusiasts will find plenty to do in David, with easy access to activities such as hiking, birdwatching, and beach outings. The nearby National Park La Barqueta is a popular spot for nature lovers, featuring miles of undisturbed coastline and diverse wildlife.

Despite its natural beauty, David remains an affordable option for those looking to relocate or travel. The city’s well-maintained infrastructure and accessibility make it a desirable destination for individuals and families seeking a balance of modern conveniences and natural allure. 

The river running through David, Panama.
The river running through David, Panama.

8. Boquete

Nestled in the lush highlands of Panama, Boquete is a haven for outdoor enthusiasts and nature lovers. The town’s stunning scenery sets the stage for a wide array of eco-friendly activities and adventures. Hiking is a major highlight, with the famous Lost Waterfalls trail offering the opportunity to explore three breathtaking waterfalls hidden within the dense cloud forest.

Boquete is also renowned for its coffee plantations, and tours of these working farms give visitors a firsthand look at the coffee-making process while offering a chance to sample some of the world’s finest brews.

For the more adventurous traveler, the climb to the summit of Volcán Barú, Panama’s highest peak, promises sweeping 360-degree views of both the Pacific and Atlantic oceans at the top. The challenging ascent provides a sense of accomplishment and rewards climbers with an unforgettable sunrise or sunset experience.

In Boquete, there’s no shortage of unique experiences and opportunities to connect with nature. Whether it’s exploring waterfalls, learning about coffee production, or conquering a volcanic summit, this charming town is a paradise for outdoor adventure enthusiasts.

Boquete is one of the best cities in Panama to visit
Aerial shot of Boquete, Panama

9. Colón

Colón, located at the entrance of the Panama Canal and near the Caribbean Sea, offers a diverse range of attractions and activities for tourists. The Agua Clara Locks Visitor Centre is a must-see, allowing visitors to witness the inner-workings of the Panama Canal and learn about its history. Another popular site is Fort San Lorenzo, a UNESCO World Heritage site with stunning views and a rich history.

For outdoor enthusiasts, Colón is a paradise for fishing, surfing, snorkeling, and scuba diving. The surrounding waters are teeming with marine life and colorful coral reefs, making it a perfect destination for underwater exploration.

Colón’s significance as the entrance to the Panama Canal and its proximity to the Caribbean Sea make it a unique and highly visited destination. The best time to visit Colón is during the dry season, from December to April, when the weather is pleasant and the water activities are at their best.

Colon is one of the best cities in Panama to visit
Skyline of Colon, Panama.

10. Santa Catalina

Tucked away on the Pacific coast of Panama, Santa Catalina is a hidden gem for travelers seeking a laid-back atmosphere and world-class surfing. While not really a ‘city’, the island is a definite must visit for travelers looking to break away from the traditional places of Panama. This charming fishing village is renowned for its consistent waves, making it a haven for surfers of all levels. In addition to its surfing reputation, Santa Catalina is also a gateway to the nearby Coiba National Park, a UNESCO World Heritage Site known for its diverse marine life and pristine beaches. Visitors can easily access the park for snorkeling and diving tours, where they can witness a vibrant underwater world teeming with colorful fish, dolphins, sharks, and rays. For those looking to explore the surrounding landscapes, horseback riding trails offer a unique way to experience the natural beauty of the area. And for those simply seeking relaxation, the palm-lined beaches are the perfect spot to unwind and enjoy the breathtaking sunsets. Whether you’re an adventure seeker or a leisure traveler, Santa Catalina offers something for everyone in a tranquil and inviting setting.

Santa Catalina is one of the best cities in Panama to visit.
Drone shot of Santa Catalina. Photo by dronepicr on Flickr.

11. Penonome

Penonome is the capital city of the Cocle province, located just a short 75-minute drive from Panama City. This vibrant city is known for its mild tropical climate, rich indigenous history, and annual festivals dedicated to oranges, sugarcane, and tomatoes. The warm climate and fertile land make it an ideal location for orchards, ranches, and rolling hills, providing a picturesque backdrop to the city.

Penonome is rich in indigenous history, with several indigenous communities still residing in the surrounding areas. The city’s annual festivals celebrate the region’s agricultural heritage, with lively parades, music, and traditional dances.

The outskirts of Penonome are teeming with wildlife, from colorful tropical birds to lush vegetation. The area is also known for its sprawling orchards, where visitors can pick fresh fruit and enjoy the serene countryside.

Penonome offers a perfect blend of cultural heritage, natural beauty, and agricultural abundance. This city is a must-visit for those looking to experience the vibrant traditions and lush landscapes of Panama.

One of the best cities in Panama is Penonome!
A church in Penonome, Panama.

12. Venao

With its pristine beaches and world-class surfing waves, Venao has rapidly transformed into a top destination for beach lovers and water sports enthusiasts. This charming coastal town, located on the Azuero Peninsula in Panama, offers a laid-back atmosphere that attracts travelers seeking relaxation and adventure. The tranquil ambiance and breathtaking natural beauty of Venao make it an ideal spot for those looking to unwind and reconnect with nature.

The presence of popular accommodation options like Selina has also contributed to Venao’s growing appeal. Selina offers a range of comfortable and stylish accommodations, from private rooms to cozy dormitories, making it a favorite choice for budget-conscious travelers and digital nomads.

The relaxed vibe, stunning beaches, and excellent surfing conditions make it a must-visit destination for anyone exploring Panama’s Pacific coast.

One of the best cities in Panama is Venao for its stunning beaches.
The beach at Venao, Panama

13. Chitre

Chitre, located in the Herrera province of Panama, is a charming town known for its rich culture and historical significance. It is the gateway to the Azuero Peninsula, which is famous for its traditional festivals, artisans, and beautiful beaches. The town is conveniently located within a few hours’ drive from Panama City, making it an easily accessible destination for both locals and tourists.

The town hosts an annual Carnaval festival, one of the most vibrant and lively celebrations in Panama. During Carnaval, the streets come alive with colorful parades, traditional music, and dancing, providing a unique and unforgettable experience for all who attend.

With its proximity to the Azuero Peninsula and Panama City, as well as its lively Carnaval festival, Chitre is a dynamic and convenient destination for those looking to experience the best of Panama’s culture and attractions. Whether it’s exploring the nearby beaches, immersing oneself in local traditions, or enjoying the modern amenities of the town, Chitre has something to offer for everyone.

Panama Bay view from Chitre, one of the best cities in Panama
The view of Panama Bay from Chitre.

14. Vacamonte

Vacamonte is a charming port city located in Panama’s Pacific region, known for its year-round maritime climate and stunning natural beauty. This coastal gem is a hotspot for deep-sea fishing, attracting fishing enthusiasts from all over the world eager to reel in marlin, sailfish, and tuna. The city is also popular for its white sand beaches, perfect for sunbathing and relaxation.

The lush natural setting of Vacamonte provides a picturesque backdrop for outdoor activities such as hiking, bird watching, and exploring the surrounding mangrove forests. Visitors can unwind amidst the tranquil beauty of the area while enjoying the warm ocean breeze and breathtaking sunsets.

As a tourist destination in Panama, Vacamonte offers a unique blend of outdoor recreation, local culture, and seaside relaxation. The city’s proximity to Panama City also makes it an accessible getaway for both locals and international travelers. With its abundant marine life, pristine beaches, and vibrant culture, Vacamonte is a must-visit destination for those seeking a coastal escape in Panama.

Read More: Things to do in Casco Viejo Panama

15. Cristobal

Cristobal is a vibrant city located in Panama, situated on a narrow isthmus connecting Manzanillo Island with the mainland. This strategic location has made Cristobal an integral part of the Panama Canal, which is one of its major attractions. Visitors can witness the marvels of engineering as they watch ships traverse through the locks of the canal, an experience that offers a unique perspective on global trade and transportation.

In addition to the Panama Canal, Cristobal is also known for its vibrant local marketplace, where visitors can immerse themselves in the local culture and find an array of goods, from fresh produce to handmade crafts. The marketplace offers a bustling and colorful environment that gives insight into the daily lives of the locals.

Overall, Cristobal offers a blend of modern industry with local traditions, making it a fascinating destination for those interested in the intersection of commerce and culture.

Best cities in Panamas to visit

Final Thoughts 

While many travelers focus on Panama City, the country has plenty of vibrant cities. Panama not only boasts a rich cultural heritage but also serves as a bridge between two continents, offering a seamless blend of tradition and modernity. As you plan your journey to this tropical paradise, remember that Panama’s beauty extends far beyond its famous canal. Whether you’re an adventure seeker, history buff, or beach lover, Panama invites you to uncover its treasures and create memories that will linger long after you’ve left its welcoming shores. 

Read More about Panama

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Visiting San Blas Islands, Panama

Best Things to do in Bocas del Toro, Panama

Save “Best Cities in Panama” for Later

Best Cities in Panama to visit
Best Cities in Panama to visit
Best Cities in Panama to visit

5 thoughts on “15 Best Cities in Panama to Visit”

  1. This makes me look forward to a Panama getaway. The closest I have made it in the past is Costa Rica, but I think Panama now needs to be on my list.

  2. I’ve only ever done an all inclusive in Panama and it’s been on my list to go back and explore. this was a great summary!

  3. this is a ton and SO insightful! i never knew there’d be much apart from panama city, i imagine this’d come in super handy for anyone heading over soon!

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